Antigenic Variation in Trypanosoma brucei: Joining the DOTs
نویسندگان
چکیده
منابع مشابه
Ku heterodimer-independent end joining in Trypanosoma brucei cell extracts relies upon sequence microhomology.
DNA double-strand breaks (DSBs) are repaired primarily by two distinct pathways: homologous recombination and nonhomologous end joining (NHEJ). NHEJ has been found in all eukaryotes examined to date and has been described recently for some bacterial species, illustrating its ancestry. Trypanosoma brucei is a divergent eukaryotic protist that evades host immunity by antigenic variation, a proces...
متن کاملSequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes
Genetic diversity in fungi and mammals is generated through mitotic double-strand break-repair (DSBR), typically involving homologous recombination (HR) or non-homologous end joining (NHEJ). Microhomology-mediated joining appears to serve a subsidiary function. The African trypanosome, a divergent protozoan parasite, relies upon rearrangement of subtelomeric variant surface glycoprotein (VSG) g...
متن کاملMicrohomology-mediated deletion and gene conversion in African trypanosomes
Antigenic variation in African trypanosomes is induced by DNA double-strand breaks (DSBs). In these protozoan parasites, DSB repair (DSBR) is dominated by homologous recombination (HR) and microhomology-mediated end joining (MMEJ), while non-homologous end joining (NHEJ) has not been reported. To facilitate the analysis of chromosomal end-joining, we established a system whereby inter-allelic r...
متن کاملAntigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.
Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis ("sleeping sickness") across sub-Saharan Africa and is a model system for antigenic variation, surviving by periodically replacing a monolayer of variant surface glycoproteins (VSG) that covers it...
متن کاملMechanisms mediating antigenic variation in Trypanosoma brucei.
Antigenic variation in Trypanosoma brucei is a highly sophisticated survival strategy involving switching between the transcription of one of an estimated thousand variant surface glycoprotein (VSG) genes. Switching involves either transcriptional control, resulting in switching between different VSG expression sites; or DNA rearrangement events slotting previously inactive VSG genes into an ac...
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ورودعنوان ژورنال:
- PLoS Biology
دوره 6 شماره
صفحات -
تاریخ انتشار 2008